Linking Oxidative Stress and DNA Damage to Changes in the Expression of Extracellular Matrix Components
Cells are subjected to endogenous [e.g., reactive oxygen species (ROS), replication stress] and exogenous insults (e.g., UV light, ionizing radiation, and certain chemicals), which can affect the synthesis and/or stability of different macromolecules required for cell and tissue function.Oxidative stress, caused by excess ROS, and DNA damage, trigg